If you’re considering egg freezing, it is important to prepare your body as if you were trying to conceive now. The goal is to optimize your egg quality before retrieval. Not all women need supplements, and taking the wrong supplements without proper guidance can do more harm than good. Every woman is unique. Some may need to improve their nutritional intake, others may have autoimmune conditions requiring specific supplementation or treatment, and some may not require supplements at all. A full blood test is the first step to determine individual needs before starting supplementation.
First Step: Blood Test and Medical Evaluation
Before adding any supplements, your doctor should assess:
Vitamin and mineral levels, including Vitamin D, Zinc, iron studies, and others depending on your risk factors and health history
Hormone balance, typically including follicle stimulating hormone (FSH), estradiol, and luteinizing hormone (LH). (Learn more about the hormones tested before and during egg freezing)
Ovarian reserve - an estimate of how many eggs you have remaining, tested by measuring your anti-mullerian hormone (AMH) levels
Other labwork depending on your medical history
This personalized approach ensures you get exactly what your body needs to support egg quality and hormonal health.
Key Supplements for Egg Freezing
Omega-3 Fatty Acids
Reduce inflammation and improve hormonal balance
Helps in conditions like PCOS, endometriosis, and PMS
Best sourced from wild-caught fish (sardines, anchovies) or algae-based options for vegetarians/vegans (look for options with both DHA and EPA.)
Zinc
Essential for follicle growth and egg maturation
Deficiency may disrupt early follicle development
Should only be taken if a blood test confirms low levels
Selenium
Antioxidant properties help protect egg cells from oxidative stress
Supports overall reproductive health
Often sufficient through diet but should be tested before supplementing
Myo-Inositol (Especially for Women with PCOS)
Improves insulin sensitivity and ovulation
Supports egg quality and hormonal regulation
Optimal formulation: 40:1 ratio of myo-inositol to d-chiro-inositol
Vitamin B6 (Pyridoxine)
Supports hormone regulation and egg development
May improve cervical mucus quality which is beneficial for later conception
Vitamin D
Vitamin D deficiency is linked to poor ovarian reserve
Supports AMH levels, ovulation, and embryo implantation
Important for women with PCOS to improve insulin resistance
Antioxidants (Vitamin E, Vitamin C, CoQ10, Resveratrol, Turmeric, Magnesium, alpha-lipoic acid)
Protect egg cells from free radicals that can cause oxidative damage. (Read more about how CoQ10 protects against oxidative damage.)
Antioxidants are found in berries, leafy greens, dark chocolate, and many other foods and fertility-focused supplements
Why Personalized Supplementation Matters
Not all supplements are necessary for every woman who will freeze their eggs. While some will benefit from targeted support, others may not need any additional intake if they already have optimal nutrient levels through a well-balanced diet. Working with a fertility specialist ensures safe and effective supplementation. Supplements are not well regulated, and many companies do not undergo rigorous third party testing for quality control.
To maximize egg quality, consider the following:
Get bloodwork done before starting any new supplements
Consult with a fertility specialist for personalized guidance
Optimize your diet and lifestyle alongside supplements in the lead up to your egg freezing cycle
Plan, and complete, your egg freezing cycle with a well-prepared body
Dr. Katharina Spies is a gynecologist and fertility specialist, as well as Medical Director of Vida Fertility Madrid. Born in Munich, Dr. Spies studied medicine in Freiburg and completed a two-year exchange program at the University of Madrid. She has led the medical team at Vida Fertility Madrid since 2022. Dr. Spies is fluent in German, French, English and Spanish and specializes in remote fertility treatments and complex cases of international patients who often come to her after a long journey.
Learn more about Vida Fertility Madrid’s egg freezing practice on Freeze.
